KDM1A-EPHB2 Fusion FISH Probe
The KDM1A-EPHB2 Fusion FISH Probe is used to confirm a fusion of the KDM1A and EPHB2 genes. The fusion of the KDM1A and EPHB2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM1A-EPHB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-RERE | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-REOR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-REGO | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-REGR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-OROR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GORE | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GROR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM1A-EPHB2-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHB2 Gene Summary
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Gene Name: EPH Receptor B2
Chromosome: CHR1: 23037330 -23241823
Locus: 1p36.12
KDM1A Gene Summary
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Gene Name: Lysine Demethylase 1A
Chromosome: CHR1: 23345940 -23410184
Locus: 1p36.12
Gene Diseases
The KDM1A EPHB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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