KDM4A-PTPRF Fusion FISH Probe
The KDM4A-PTPRF Fusion FISH Probe is used to confirm a fusion of the KDM4A and PTPRF genes. The fusion of the KDM4A and PTPRF genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KDM4A-PTPRF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-RERE | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-REOR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-REGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-REGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-REAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-ORRE | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-OROR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-ORGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-ORAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GORE | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GOOR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GOGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GOGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GOAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GRRE | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GROR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GRGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GRGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-GRAQ | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-AQRE | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-AQOR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-AQGO | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-AQGR | 20 (40 μL) | 200 μL |
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| KDM4A-PTPRF-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRF Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type F
Chromosome: CHR1: 43996546 -44089343
Locus: 1p34.2
KDM4A Gene Summary
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Gene Name: Lysine Demethylase 4A
Chromosome: CHR1: 44115796 -44171189
Locus: 1p34.2-p34.1
Gene Diseases
The KDM4A PTPRF Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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