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KIAA0146-ANK1 Fusion FISH Probe

The KIAA0146-ANK1 Fusion FISH Probe is used to confirm a fusion of the KIAA0146 and ANK1 genes. The fusion of the KIAA0146 and ANK1 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
KIAA0146-ANK1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
KIAA0146-ANK1-20-RERE 20 (40 μL) 200 μL
KIAA0146-ANK1-20-REOR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-REGO 20 (40 μL) 200 μL
KIAA0146-ANK1-20-REGR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-REAQ 20 (40 μL) 200 μL
KIAA0146-ANK1-20-ORRE 20 (40 μL) 200 μL
KIAA0146-ANK1-20-OROR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-ORGO 20 (40 μL) 200 μL
KIAA0146-ANK1-20-ORAQ 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GORE 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GOOR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GOGO 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GOGR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GOAQ 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GRRE 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GROR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GRGO 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GRGR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-GRAQ 20 (40 μL) 200 μL
KIAA0146-ANK1-20-AQRE 20 (40 μL) 200 μL
KIAA0146-ANK1-20-AQOR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-AQGO 20 (40 μL) 200 μL
KIAA0146-ANK1-20-AQGR 20 (40 μL) 200 μL
KIAA0146-ANK1-20-AQAQ 20 (40 μL) 200 μL

ANK1 Gene Summary

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]

Gene Name: Ankyrin 1

Chromosome: CHR8: 41510743 -41754280

Locus: 8p11.21

Gene Diseases

The KIAA0146 ANK1 Fusion has been associated with the following diseases:

Disease Name
Colon Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.