KIFAP3-COPA Fusion FISH Probe
The KIFAP3-COPA Fusion FISH Probe is used to confirm a fusion of the KIFAP3 and COPA genes. The fusion of the KIFAP3 and COPA genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KIFAP3-COPA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-RERE | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-REOR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-REGO | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-REGR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-REAQ | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-ORRE | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-OROR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-ORGO | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-ORAQ | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GORE | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GOOR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GOGO | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GOGR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GOAQ | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GRRE | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GROR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GRGO | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GRGR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-GRAQ | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-AQRE | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-AQOR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-AQGO | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-AQGR | 20 (40 μL) | 200 μL |
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| KIFAP3-COPA-20-AQAQ | 20 (40 μL) | 200 μL |
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COPA Gene Summary
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Coatomer Protein Complex Subunit Alpha
Chromosome: CHR1: 160258376 -160313354
Locus: 1q23.2
KIFAP3 Gene Summary
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: Kinesin Associated Protein 3
Chromosome: CHR1: 169890469 -170043879
Locus: 1q24.2
Gene Diseases
The KIFAP3 COPA Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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