KLC1-MARK3 Fusion FISH Probe
The KLC1-MARK3 Fusion FISH Probe is used to confirm a fusion of the KLC1 and MARK3 genes. The fusion of the KLC1 and MARK3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| KLC1-MARK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-RERE | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-REOR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-REGO | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-REGR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-REAQ | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-ORRE | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-OROR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-ORGO | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GORE | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GOOR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GOGO | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GOGR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GRRE | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GROR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GRGO | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GRGR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-AQRE | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-AQOR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-AQGO | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-AQGR | 20 (40 μL) | 200 μL |
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| KLC1-MARK3-20-AQAQ | 20 (40 μL) | 200 μL |
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KLC1 Gene Summary
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Kinesin Light Chain 1
Chromosome: CHR14: 104095524 -104167888
Locus: 14q32.33
MARK3 Gene Summary
The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Microtubule Affinity Regulating Kinase 3
Chromosome: CHR14: 103851700 -103970166
Locus: 14q32.32-q32.33
Gene Diseases
The KLC1 MARK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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