LAPTM4A-SDC1 Fusion FISH Probe
The LAPTM4A-SDC1 Fusion FISH Probe is used to confirm a fusion of the LAPTM4A and SDC1 genes. The fusion of the LAPTM4A and SDC1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LAPTM4A-SDC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-RERE | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-REOR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-REGO | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-REGR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-REAQ | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-ORRE | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-OROR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-ORGO | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GORE | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GOOR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GOGO | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GOGR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GRRE | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GROR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GRGO | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GRGR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-AQRE | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-AQOR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-AQGO | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-AQGR | 20 (40 μL) | 200 μL |
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| LAPTM4A-SDC1-20-AQAQ | 20 (40 μL) | 200 μL |
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SDC1 Gene Summary
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Gene Name: Syndecan 1
Chromosome: CHR2: 20400557 -20425194
Locus: 2p24.1
LAPTM4A Gene Summary
This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]
Gene Name: Lysosomal Protein Transmembrane 4 Alpha
Chromosome: CHR2: 20232410 -20251789
Locus: 2p24.1
Gene Diseases
The LAPTM4A SDC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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