LDHB-CCT5 Fusion FISH Probe
The LDHB-CCT5 Fusion FISH Probe is used to confirm a fusion of the LDHB and CCT5 genes. The fusion of the LDHB and CCT5 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LDHB-CCT5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-RERE | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-REOR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-REGO | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-REGR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-REAQ | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-ORRE | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-OROR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-ORGO | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-ORAQ | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GORE | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GOOR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GOGO | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GOGR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GOAQ | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GRRE | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GROR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GRGO | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GRGR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-GRAQ | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-AQRE | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-AQOR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-AQGO | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-AQGR | 20 (40 μL) | 200 μL |
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| LDHB-CCT5-20-AQAQ | 20 (40 μL) | 200 μL |
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LDHB Gene Summary
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
Gene Name: Lactate Dehydrogenase B
Chromosome: CHR12: 21788274 -21810789
Locus: 12p12.1
CCT5 Gene Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]
Gene Name: Chaperonin Containing TCP1 Subunit 5
Chromosome: CHR5: 10250281 -10266501
Locus: 5p15.2
Gene Diseases
The LDHB CCT5 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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