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LDLR-TNPO2 Fusion FISH Probe

The LDLR-TNPO2 Fusion FISH Probe is used to confirm a fusion of the LDLR and TNPO2 genes. The fusion of the LDLR and TNPO2 genes has been associated with Breast Invasive Carcinoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
LDLR-TNPO2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
LDLR-TNPO2-20-RERE 20 (40 μL) 200 μL
LDLR-TNPO2-20-REOR 20 (40 μL) 200 μL
LDLR-TNPO2-20-REGO 20 (40 μL) 200 μL
LDLR-TNPO2-20-REGR 20 (40 μL) 200 μL
LDLR-TNPO2-20-REAQ 20 (40 μL) 200 μL
LDLR-TNPO2-20-ORRE 20 (40 μL) 200 μL
LDLR-TNPO2-20-OROR 20 (40 μL) 200 μL
LDLR-TNPO2-20-ORGO 20 (40 μL) 200 μL
LDLR-TNPO2-20-ORAQ 20 (40 μL) 200 μL
LDLR-TNPO2-20-GORE 20 (40 μL) 200 μL
LDLR-TNPO2-20-GOOR 20 (40 μL) 200 μL
LDLR-TNPO2-20-GOGO 20 (40 μL) 200 μL
LDLR-TNPO2-20-GOGR 20 (40 μL) 200 μL
LDLR-TNPO2-20-GOAQ 20 (40 μL) 200 μL
LDLR-TNPO2-20-GRRE 20 (40 μL) 200 μL
LDLR-TNPO2-20-GROR 20 (40 μL) 200 μL
LDLR-TNPO2-20-GRGO 20 (40 μL) 200 μL
LDLR-TNPO2-20-GRGR 20 (40 μL) 200 μL
LDLR-TNPO2-20-GRAQ 20 (40 μL) 200 μL
LDLR-TNPO2-20-AQRE 20 (40 μL) 200 μL
LDLR-TNPO2-20-AQOR 20 (40 μL) 200 μL
LDLR-TNPO2-20-AQGO 20 (40 μL) 200 μL
LDLR-TNPO2-20-AQGR 20 (40 μL) 200 μL
LDLR-TNPO2-20-AQAQ 20 (40 μL) 200 μL

LDLR Gene Summary

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Gene Name: Low Density Lipoprotein Receptor

Chromosome: CHR19: 11200037 -11244505

Locus: 19p13.2

TNPO2 Gene Summary

The Transportin 2 (TNPO2) gene is located on chr19 :12810007-12834810 at 19p13.13.

Gene Name: Transportin 2

Chromosome: CHR19: 12810007 -12834810

Locus: 19p13.13

Gene Diseases

The LDLR TNPO2 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.