LIMK1-GNAT3 Fusion FISH Probe
The LIMK1-GNAT3 Fusion FISH Probe is used to confirm a fusion of the LIMK1 and GNAT3 genes. The fusion of the LIMK1 and GNAT3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LIMK1-GNAT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-RERE | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-REOR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-REGO | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-REGR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-REAQ | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-ORRE | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-OROR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-ORGO | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GORE | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GOOR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GOGO | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GOGR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GRRE | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GROR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GRGO | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GRGR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-AQRE | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-AQOR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-AQGO | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-AQGR | 20 (40 μL) | 200 μL |
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| LIMK1-GNAT3-20-AQAQ | 20 (40 μL) | 200 μL |
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LIMK1 Gene Summary
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
Gene Name: LIM Domain Kinase 1
Chromosome: CHR7: 73498106 -73536855
Locus: 7q11.23
GNAT3 Gene Summary
Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]
Gene Name: G Protein Subunit Alpha Transducin 3
Chromosome: CHR7: 80087986 -80141242
Locus: 7q21.11
Gene Diseases
The LIMK1 GNAT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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