LLGL2-EXOC7 Fusion FISH Probe
The LLGL2-EXOC7 Fusion FISH Probe is used to confirm a fusion of the LLGL2 and EXOC7 genes. The fusion of the LLGL2 and EXOC7 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LLGL2-EXOC7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-RERE | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-REOR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-REGO | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-REGR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-REAQ | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-ORRE | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-OROR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-ORGO | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-ORAQ | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GORE | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GOOR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GOGO | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GOGR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GOAQ | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GRRE | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GROR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GRGO | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GRGR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-GRAQ | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-AQRE | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-AQOR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-AQGO | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-AQGR | 20 (40 μL) | 200 μL |
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| LLGL2-EXOC7-20-AQAQ | 20 (40 μL) | 200 μL |
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LLGL2 Gene Summary
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: LLGL2, Scribble Cell Polarity Complex Component
Chromosome: CHR17: 73521782 -73571290
Locus: 17q25.1
EXOC7 Gene Summary
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
Gene Name: Exocyst Complex Component 7
Chromosome: CHR17: 74077085 -74099868
Locus: 17q25.1
Gene Diseases
The LLGL2 EXOC7 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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