LNPEP-CAST Fusion FISH Probe
The LNPEP-CAST Fusion FISH Probe is used to confirm a fusion of the LNPEP and CAST genes. The fusion of the LNPEP and CAST genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LNPEP-CAST-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-RERE | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-REOR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-REGO | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-REGR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-REAQ | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-ORRE | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-OROR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-ORGO | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-ORAQ | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GORE | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GOOR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GOGO | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GOGR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GOAQ | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GRRE | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GROR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GRGO | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GRGR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-GRAQ | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-AQRE | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-AQOR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-AQGO | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-AQGR | 20 (40 μL) | 200 μL |
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| LNPEP-CAST-20-AQAQ | 20 (40 μL) | 200 μL |
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CAST Gene Summary
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Gene Name: Calpastatin
Chromosome: CHR5: 95997740 -96110385
Locus: 5q15
LNPEP Gene Summary
This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Leucyl And Cystinyl Aminopeptidase
Chromosome: CHR5: 96271345 -96365115
Locus: 5q15
Gene Diseases
The LNPEP CAST Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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