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LPP-F2 Fusion FISH Probe

The LPP-F2 Fusion FISH Probe is used to confirm a fusion of the LPP and F2 genes. The fusion of the LPP and F2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
LPP-F2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
LPP-F2-20-RERE 20 (40 μL) 200 μL
LPP-F2-20-REOR 20 (40 μL) 200 μL
LPP-F2-20-REGO 20 (40 μL) 200 μL
LPP-F2-20-REGR 20 (40 μL) 200 μL
LPP-F2-20-REAQ 20 (40 μL) 200 μL
LPP-F2-20-ORRE 20 (40 μL) 200 μL
LPP-F2-20-OROR 20 (40 μL) 200 μL
LPP-F2-20-ORGO 20 (40 μL) 200 μL
LPP-F2-20-ORAQ 20 (40 μL) 200 μL
LPP-F2-20-GORE 20 (40 μL) 200 μL
LPP-F2-20-GOOR 20 (40 μL) 200 μL
LPP-F2-20-GOGO 20 (40 μL) 200 μL
LPP-F2-20-GOGR 20 (40 μL) 200 μL
LPP-F2-20-GOAQ 20 (40 μL) 200 μL
LPP-F2-20-GRRE 20 (40 μL) 200 μL
LPP-F2-20-GROR 20 (40 μL) 200 μL
LPP-F2-20-GRGO 20 (40 μL) 200 μL
LPP-F2-20-GRGR 20 (40 μL) 200 μL
LPP-F2-20-GRAQ 20 (40 μL) 200 μL
LPP-F2-20-AQRE 20 (40 μL) 200 μL
LPP-F2-20-AQOR 20 (40 μL) 200 μL
LPP-F2-20-AQGO 20 (40 μL) 200 μL
LPP-F2-20-AQGR 20 (40 μL) 200 μL
LPP-F2-20-AQAQ 20 (40 μL) 200 μL

F2 Gene Summary

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Gene Name: Coagulation Factor II, Thrombin

Chromosome: CHR11: 46740742 -46761056

Locus: 11p11.2

LPP Gene Summary

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Name: LIM Domain Containing Preferred Translocation Partner In Lipoma

Chromosome: CHR3: 187871662 -188608460

Locus: 3q27.3-q28

Gene Diseases

The LPP F2 Fusion has been associated with the following diseases:

Disease Name
Ovarian Serous Cystadenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.