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LRP5-VPS37C Fusion FISH Probe

The LRP5-VPS37C Fusion FISH Probe is used to confirm a fusion of the LRP5 and VPS37C genes. The fusion of the LRP5 and VPS37C genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
LRP5-VPS37C-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
LRP5-VPS37C-20-RERE 20 (40 μL) 200 μL
LRP5-VPS37C-20-REOR 20 (40 μL) 200 μL
LRP5-VPS37C-20-REGO 20 (40 μL) 200 μL
LRP5-VPS37C-20-REGR 20 (40 μL) 200 μL
LRP5-VPS37C-20-REAQ 20 (40 μL) 200 μL
LRP5-VPS37C-20-ORRE 20 (40 μL) 200 μL
LRP5-VPS37C-20-OROR 20 (40 μL) 200 μL
LRP5-VPS37C-20-ORGO 20 (40 μL) 200 μL
LRP5-VPS37C-20-ORAQ 20 (40 μL) 200 μL
LRP5-VPS37C-20-GORE 20 (40 μL) 200 μL
LRP5-VPS37C-20-GOOR 20 (40 μL) 200 μL
LRP5-VPS37C-20-GOGO 20 (40 μL) 200 μL
LRP5-VPS37C-20-GOGR 20 (40 μL) 200 μL
LRP5-VPS37C-20-GOAQ 20 (40 μL) 200 μL
LRP5-VPS37C-20-GRRE 20 (40 μL) 200 μL
LRP5-VPS37C-20-GROR 20 (40 μL) 200 μL
LRP5-VPS37C-20-GRGO 20 (40 μL) 200 μL
LRP5-VPS37C-20-GRGR 20 (40 μL) 200 μL
LRP5-VPS37C-20-GRAQ 20 (40 μL) 200 μL
LRP5-VPS37C-20-AQRE 20 (40 μL) 200 μL
LRP5-VPS37C-20-AQOR 20 (40 μL) 200 μL
LRP5-VPS37C-20-AQGO 20 (40 μL) 200 μL
LRP5-VPS37C-20-AQGR 20 (40 μL) 200 μL
LRP5-VPS37C-20-AQAQ 20 (40 μL) 200 μL

LRP5 Gene Summary

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Name: LDL Receptor Related Protein 5

Chromosome: CHR11: 68080107 -68216743

Locus: 11q13.2

VPS37C Gene Summary

VPS37C is a subunit of ESCRT-I (endosomal sorting complex required for transport I), a complex in the class E vacuolar protein sorting (VPS) pathway required for sorting ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies (Eastman et al., 2005 [PubMed 15509564]).[supplied by OMIM, Mar 2008]

Gene Name: VPS37C, ESCRT-I Subunit

Chromosome: CHR11: 60897727 -60928916

Locus: 11q12.2

Gene Diseases

The LRP5 VPS37C Fusion has been associated with the following diseases:

Disease Name
Brain Lower Grade Glioma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.