LRP6-DUSP16 Fusion FISH Probe
The LRP6-DUSP16 Fusion FISH Probe is used to confirm a fusion of the LRP6 and DUSP16 genes. The fusion of the LRP6 and DUSP16 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP6-DUSP16-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-RERE | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-REOR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-REGO | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-REGR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-OROR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GORE | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GROR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP6-DUSP16-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP6 Gene Summary
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Gene Name: LDL Receptor Related Protein 6
Chromosome: CHR12: 12268960 -12419811
Locus: 12p13.2
DUSP16 Gene Summary
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]
Gene Name: Dual Specificity Phosphatase 16
Chromosome: CHR12: 12626215 -12715448
Locus: 12p13.2
Gene Diseases
The LRP6 DUSP16 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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