LRP8-PAX8 Fusion FISH Probe
The LRP8-PAX8 Fusion FISH Probe is used to confirm a fusion of the LRP8 and PAX8 genes. The fusion of the LRP8 and PAX8 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP8-PAX8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-RERE | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-REOR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-REGO | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-REGR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-OROR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GORE | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GROR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP8-PAX8-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP8 Gene Summary
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
Gene Name: LDL Receptor Related Protein 8
Chromosome: CHR1: 53708040 -53793821
Locus: 1p32.3
PAX8 Gene Summary
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Gene Name: Paired Box 8
Chromosome: CHR2: 113973573 -114036498
Locus: 2q13
Gene Diseases
The LRP8 PAX8 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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