LRP8-USP24 Fusion FISH Probe
The LRP8-USP24 Fusion FISH Probe is used to confirm a fusion of the LRP8 and USP24 genes. The fusion of the LRP8 and USP24 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| LRP8-USP24-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-RERE | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-REOR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-REGO | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-REGR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-REAQ | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-ORRE | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-OROR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-ORGO | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-ORAQ | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GORE | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GOOR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GOGO | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GOGR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GOAQ | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GRRE | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GROR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GRGO | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GRGR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-GRAQ | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-AQRE | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-AQOR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-AQGO | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-AQGR | 20 (40 μL) | 200 μL |
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| LRP8-USP24-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP8 Gene Summary
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
Gene Name: LDL Receptor Related Protein 8
Chromosome: CHR1: 53708040 -53793821
Locus: 1p32.3
USP24 Gene Summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Gene Name: Ubiquitin Specific Peptidase 24
Chromosome: CHR1: 55532031 -55681039
Locus: 1p32.3
Gene Diseases
The LRP8 USP24 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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