MAP2K2-RP11-87C12.2 Fusion FISH Probe
The MAP2K2-RP11-87C12.2 Fusion FISH Probe is used to confirm a fusion of the MAP2K2 and RP11-87C12.2 genes. The fusion of the MAP2K2 and RP11-87C12.2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP2K2-RP11-87C12.2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-RERE | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-REOR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-REGO | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-REGR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-OROR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GORE | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GROR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP2K2-RP11-87C12.2-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP2K2 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase 2
Chromosome: CHR19: 4090319 -4124126
Locus: 19p13.3
Gene Diseases
The MAP2K2 RP11-87C12.2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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