MAP2K4-PSMD12 Fusion FISH Probe
The MAP2K4-PSMD12 Fusion FISH Probe is used to confirm a fusion of the MAP2K4 and PSMD12 genes. The fusion of the MAP2K4 and PSMD12 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP2K4-PSMD12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-RERE | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-REOR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-REGO | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-REGR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-OROR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GORE | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GROR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP2K4-PSMD12-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD12 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Proteasome 26S Subunit, Non-ATPase 12
Chromosome: CHR17: 65336618 -65362721
Locus: 17q24.2
MAP2K4 Gene Summary
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Mitogen-activated Protein Kinase Kinase 4
Chromosome: CHR17: 11924134 -12047051
Locus: 17p12
Gene Diseases
The MAP2K4 PSMD12 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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