MAP2K5-SMAD6 Fusion FISH Probe
The MAP2K5-SMAD6 Fusion FISH Probe is used to confirm a fusion of the MAP2K5 and SMAD6 genes. The fusion of the MAP2K5 and SMAD6 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP2K5-SMAD6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-RERE | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-REOR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-REGO | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-REGR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-OROR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GORE | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GROR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP2K5-SMAD6-20-AQAQ | 20 (40 μL) | 200 μL |
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SMAD6 Gene Summary
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]
Gene Name: SMAD Family Member 6
Chromosome: CHR15: 66994673 -67074337
Locus: 15q22.31
MAP2K5 Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Gene Name: Mitogen-activated Protein Kinase Kinase 5
Chromosome: CHR15: 67835020 -68099455
Locus: 15q23
Gene Diseases
The MAP2K5 SMAD6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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