MAP3K3-BRIP1 Fusion FISH Probe
The MAP3K3-BRIP1 Fusion FISH Probe is used to confirm a fusion of the MAP3K3 and BRIP1 genes. The fusion of the MAP3K3 and BRIP1 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K3-BRIP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K3-BRIP1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K3 Gene Summary
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 3
Chromosome: CHR17: 61699800 -61773670
Locus: 17q23.3
BRIP1 Gene Summary
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
Gene Name: BRCA1 Interacting Protein C-terminal Helicase 1
Chromosome: CHR17: 59756546 -59940920
Locus: 17q23.2
Gene Diseases
The MAP3K3 BRIP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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