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MAP3K5-PREP Fusion FISH Probe

The MAP3K5-PREP Fusion FISH Probe is used to confirm a fusion of the MAP3K5 and PREP genes. The fusion of the MAP3K5 and PREP genes has been associated with Uveal Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MAP3K5-PREP-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MAP3K5-PREP-20-RERE 20 (40 μL) 200 μL
MAP3K5-PREP-20-REOR 20 (40 μL) 200 μL
MAP3K5-PREP-20-REGO 20 (40 μL) 200 μL
MAP3K5-PREP-20-REGR 20 (40 μL) 200 μL
MAP3K5-PREP-20-REAQ 20 (40 μL) 200 μL
MAP3K5-PREP-20-ORRE 20 (40 μL) 200 μL
MAP3K5-PREP-20-OROR 20 (40 μL) 200 μL
MAP3K5-PREP-20-ORGO 20 (40 μL) 200 μL
MAP3K5-PREP-20-ORAQ 20 (40 μL) 200 μL
MAP3K5-PREP-20-GORE 20 (40 μL) 200 μL
MAP3K5-PREP-20-GOOR 20 (40 μL) 200 μL
MAP3K5-PREP-20-GOGO 20 (40 μL) 200 μL
MAP3K5-PREP-20-GOGR 20 (40 μL) 200 μL
MAP3K5-PREP-20-GOAQ 20 (40 μL) 200 μL
MAP3K5-PREP-20-GRRE 20 (40 μL) 200 μL
MAP3K5-PREP-20-GROR 20 (40 μL) 200 μL
MAP3K5-PREP-20-GRGO 20 (40 μL) 200 μL
MAP3K5-PREP-20-GRGR 20 (40 μL) 200 μL
MAP3K5-PREP-20-GRAQ 20 (40 μL) 200 μL
MAP3K5-PREP-20-AQRE 20 (40 μL) 200 μL
MAP3K5-PREP-20-AQOR 20 (40 μL) 200 μL
MAP3K5-PREP-20-AQGO 20 (40 μL) 200 μL
MAP3K5-PREP-20-AQGR 20 (40 μL) 200 μL
MAP3K5-PREP-20-AQAQ 20 (40 μL) 200 μL

MAP3K5 Gene Summary

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]

Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 5

Chromosome: CHR6: 136878186 -137113656

Locus: 6q23.3

PREP Gene Summary

The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008]

Gene Name: Prolyl Endopeptidase

Chromosome: CHR6: 105725441 -105850999

Locus: 6q21

Gene Diseases

The MAP3K5 PREP Fusion has been associated with the following diseases:

Disease Name
Uveal Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.