MAP3K7-COL12A1 Fusion FISH Probe
The MAP3K7-COL12A1 Fusion FISH Probe is used to confirm a fusion of the MAP3K7 and COL12A1 genes. The fusion of the MAP3K7 and COL12A1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K7-COL12A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K7-COL12A1-20-AQAQ | 20 (40 μL) | 200 μL |
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COL12A1 Gene Summary
This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Collagen Type XII Alpha 1 Chain
Chromosome: CHR6: 75794041 -75915623
Locus: 6q13-q14.1
MAP3K7 Gene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 7
Chromosome: CHR6: 91225352 -91296907
Locus: 6q15
Gene Diseases
The MAP3K7 COL12A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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