MAP3K8-LYZL2 Fusion FISH Probe
The MAP3K8-LYZL2 Fusion FISH Probe is used to confirm a fusion of the MAP3K8 and LYZL2 genes. The fusion of the MAP3K8 and LYZL2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP3K8-LYZL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-RERE | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-REOR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-REGO | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-REGR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-OROR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GORE | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GROR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP3K8-LYZL2-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP3K8 Gene Summary
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase 8
Chromosome: CHR10: 30722949 -30750762
Locus: 10p11.23
LYZL2 Gene Summary
Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Gene Name: Lysozyme Like 2
Chromosome: CHR10: 30900707 -30918647
Locus: 10p11.23
Gene Diseases
The MAP3K8 LYZL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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