MAP4K2-NETO2 Fusion FISH Probe
The MAP4K2-NETO2 Fusion FISH Probe is used to confirm a fusion of the MAP4K2 and NETO2 genes. The fusion of the MAP4K2 and NETO2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAP4K2-NETO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-RERE | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-REOR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-REGO | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-REGR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-REAQ | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-ORRE | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-OROR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-ORGO | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GORE | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GOOR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GOGO | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GOGR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GRRE | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GROR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GRGO | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GRGR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-AQRE | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-AQOR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-AQGO | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-AQGR | 20 (40 μL) | 200 μL |
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| MAP4K2-NETO2-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP4K2 Gene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: Mitogen-activated Protein Kinase Kinase Kinase Kinase 2
Chromosome: CHR11: 64556608 -64570713
Locus: 11q13.1
NETO2 Gene Summary
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Name: Neuropilin And Tolloid Like 2
Chromosome: CHR16: 47115430 -47177936
Locus: 16q12.1
Gene Diseases
The MAP4K2 NETO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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