MAPK1-KCNJ4 Fusion FISH Probe
The MAPK1-KCNJ4 Fusion FISH Probe is used to confirm a fusion of the MAPK1 and KCNJ4 genes. The fusion of the MAPK1 and KCNJ4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK1-KCNJ4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK1-KCNJ4-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNJ4 Gene Summary
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Potassium Voltage-gated Channel Subfamily J Member 4
Chromosome: CHR22: 38822332 -38851203
Locus: 22q13.1
MAPK1 Gene Summary
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Mitogen-activated Protein Kinase 1
Chromosome: CHR22: 22113946 -22221970
Locus: 22q11.22
Gene Diseases
The MAPK1 KCNJ4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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