MAPK1-PRODH Fusion FISH Probe
The MAPK1-PRODH Fusion FISH Probe is used to confirm a fusion of the MAPK1 and PRODH genes. The fusion of the MAPK1 and PRODH genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK1-PRODH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK1-PRODH-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK1 Gene Summary
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Mitogen-activated Protein Kinase 1
Chromosome: CHR22: 22113946 -22221970
Locus: 22q11.22
PRODH Gene Summary
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Name: Proline Dehydrogenase 1
Chromosome: CHR22: 18900286 -18924066
Locus: 22q11.21
Gene Diseases
The MAPK1 PRODH Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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