MAPK1-TOP3B Fusion FISH Probe
The MAPK1-TOP3B Fusion FISH Probe is used to confirm a fusion of the MAPK1 and TOP3B genes. The fusion of the MAPK1 and TOP3B genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK1-TOP3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK1-TOP3B-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK1 Gene Summary
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Mitogen-activated Protein Kinase 1
Chromosome: CHR22: 22113946 -22221970
Locus: 22q11.22
TOP3B Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Gene Name: DNA Topoisomerase III Beta
Chromosome: CHR22: 22311402 -22337147
Locus: 22q11.22
Gene Diseases
The MAPK1 TOP3B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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