MAPK10-ARHGAP24 Fusion FISH Probe
The MAPK10-ARHGAP24 Fusion FISH Probe is used to confirm a fusion of the MAPK10 and ARHGAP24 genes. The fusion of the MAPK10 and ARHGAP24 genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK10-ARHGAP24-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK10-ARHGAP24-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK10 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Gene Name: Mitogen-activated Protein Kinase 10
Chromosome: CHR4: 86936275 -87374283
Locus: 4q21.3
ARHGAP24 Gene Summary
This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Gene Name: Rho GTPase Activating Protein 24
Chromosome: CHR4: 86396283 -86923823
Locus: 4q21.23-q21.3
Gene Diseases
The MAPK10 ARHGAP24 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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