MAPK10-PTPN13 Fusion FISH Probe
The MAPK10-PTPN13 Fusion FISH Probe is used to confirm a fusion of the MAPK10 and PTPN13 genes. The fusion of the MAPK10 and PTPN13 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK10-PTPN13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK10-PTPN13-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK10 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Gene Name: Mitogen-activated Protein Kinase 10
Chromosome: CHR4: 86936275 -87374283
Locus: 4q21.3
PTPN13 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 13
Chromosome: CHR4: 87515467 -87736328
Locus: 4q21.3
Gene Diseases
The MAPK10 PTPN13 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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