MAPK14-ANK1 Fusion FISH Probe
The MAPK14-ANK1 Fusion FISH Probe is used to confirm a fusion of the MAPK14 and ANK1 genes. The fusion of the MAPK14 and ANK1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK14-ANK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK14-ANK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ANK1 Gene Summary
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
Gene Name: Ankyrin 1
Chromosome: CHR8: 41510743 -41754280
Locus: 8p11.21
MAPK14 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Mitogen-activated Protein Kinase 14
Chromosome: CHR6: 35995453 -36079013
Locus: 6p21.31
Gene Diseases
The MAPK14 ANK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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