MAPK8-C10ORF53 Fusion FISH Probe
The MAPK8-C10ORF53 Fusion FISH Probe is used to confirm a fusion of the MAPK8 and C10ORF53 genes. The fusion of the MAPK8 and C10ORF53 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MAPK8-C10ORF53-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-RERE | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-REOR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-REGO | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-REGR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-REAQ | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-ORRE | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-OROR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-ORGO | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-ORAQ | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GORE | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GOOR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GOGO | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GOGR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GOAQ | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GRRE | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GROR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GRGO | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GRGR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-GRAQ | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-AQRE | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-AQOR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-AQGO | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-AQGR | 20 (40 μL) | 200 μL |
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| MAPK8-C10ORF53-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPK8 Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Gene Name: Mitogen-activated Protein Kinase 8
Chromosome: CHR10: 49609686 -49643183
Locus: 10q11.22
C10orf53 Gene Summary
The Chromosome 10 Open Reading Frame 53 (C10orf53) gene is located on chr10 :50887683-50916956 at 10q11.23.
Gene Name: Chromosome 10 Open Reading Frame 53
Chromosome: CHR10: 50887683 -50916956
Locus: 10q11.23
Gene Diseases
The MAPK8 C10ORF53 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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