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MDK-SEC63 Fusion FISH Probe

The MDK-SEC63 Fusion FISH Probe is used to confirm a fusion of the MDK and SEC63 genes. The fusion of the MDK and SEC63 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MDK-SEC63-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MDK-SEC63-20-RERE 20 (40 μL) 200 μL
MDK-SEC63-20-REOR 20 (40 μL) 200 μL
MDK-SEC63-20-REGO 20 (40 μL) 200 μL
MDK-SEC63-20-REGR 20 (40 μL) 200 μL
MDK-SEC63-20-REAQ 20 (40 μL) 200 μL
MDK-SEC63-20-ORRE 20 (40 μL) 200 μL
MDK-SEC63-20-OROR 20 (40 μL) 200 μL
MDK-SEC63-20-ORGO 20 (40 μL) 200 μL
MDK-SEC63-20-ORAQ 20 (40 μL) 200 μL
MDK-SEC63-20-GORE 20 (40 μL) 200 μL
MDK-SEC63-20-GOOR 20 (40 μL) 200 μL
MDK-SEC63-20-GOGO 20 (40 μL) 200 μL
MDK-SEC63-20-GOGR 20 (40 μL) 200 μL
MDK-SEC63-20-GOAQ 20 (40 μL) 200 μL
MDK-SEC63-20-GRRE 20 (40 μL) 200 μL
MDK-SEC63-20-GROR 20 (40 μL) 200 μL
MDK-SEC63-20-GRGO 20 (40 μL) 200 μL
MDK-SEC63-20-GRGR 20 (40 μL) 200 μL
MDK-SEC63-20-GRAQ 20 (40 μL) 200 μL
MDK-SEC63-20-AQRE 20 (40 μL) 200 μL
MDK-SEC63-20-AQOR 20 (40 μL) 200 μL
MDK-SEC63-20-AQGO 20 (40 μL) 200 μL
MDK-SEC63-20-AQGR 20 (40 μL) 200 μL
MDK-SEC63-20-AQAQ 20 (40 μL) 200 μL

MDK Gene Summary

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Gene Name: Midkine

Chromosome: CHR11: 46402617 -46405375

Locus: 11p11.2

SEC63 Gene Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

Gene Name: SEC63 Homolog, Protein Translocation Regulator

Chromosome: CHR6: 108188959 -108279482

Locus: 6q21

Gene Diseases

The MDK SEC63 Fusion has been associated with the following diseases:

Disease Name
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.