MDM1-INSR Fusion FISH Probe
The MDM1-INSR Fusion FISH Probe is used to confirm a fusion of the MDM1 and INSR genes. The fusion of the MDM1 and INSR genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MDM1-INSR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-RERE | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-REOR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-REGO | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-REGR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-REAQ | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-ORRE | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-OROR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-ORGO | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-ORAQ | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GORE | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GOOR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GOGO | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GOGR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GOAQ | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GRRE | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GROR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GRGO | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GRGR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-GRAQ | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-AQRE | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-AQOR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-AQGO | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-AQGR | 20 (40 μL) | 200 μL |
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| MDM1-INSR-20-AQAQ | 20 (40 μL) | 200 μL |
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INSR Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Insulin Receptor
Chromosome: CHR19: 7112265 -7294011
Locus: 19p13.2
MDM1 Gene Summary
This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells, and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. naturally occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Aug 2017]
Gene Name: Mdm1 Nuclear Protein
Chromosome: CHR12: 68688345 -68726161
Locus: 12q15
Gene Diseases
The MDM1 INSR Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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