SEARCH OUR PRODUCT CATALOG

MDM2-NUP107 Fusion FISH Probe

The MDM2-NUP107 Fusion FISH Probe is used to confirm a fusion of the MDM2 and NUP107 genes. The fusion of the MDM2 and NUP107 genes has been associated with Breast Invasive Carcinoma, Lung Adenocarcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MDM2-NUP107-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MDM2-NUP107-20-RERE 20 (40 μL) 200 μL
MDM2-NUP107-20-REOR 20 (40 μL) 200 μL
MDM2-NUP107-20-REGO 20 (40 μL) 200 μL
MDM2-NUP107-20-REGR 20 (40 μL) 200 μL
MDM2-NUP107-20-REAQ 20 (40 μL) 200 μL
MDM2-NUP107-20-ORRE 20 (40 μL) 200 μL
MDM2-NUP107-20-OROR 20 (40 μL) 200 μL
MDM2-NUP107-20-ORGO 20 (40 μL) 200 μL
MDM2-NUP107-20-ORAQ 20 (40 μL) 200 μL
MDM2-NUP107-20-GORE 20 (40 μL) 200 μL
MDM2-NUP107-20-GOOR 20 (40 μL) 200 μL
MDM2-NUP107-20-GOGO 20 (40 μL) 200 μL
MDM2-NUP107-20-GOGR 20 (40 μL) 200 μL
MDM2-NUP107-20-GOAQ 20 (40 μL) 200 μL
MDM2-NUP107-20-GRRE 20 (40 μL) 200 μL
MDM2-NUP107-20-GROR 20 (40 μL) 200 μL
MDM2-NUP107-20-GRGO 20 (40 μL) 200 μL
MDM2-NUP107-20-GRGR 20 (40 μL) 200 μL
MDM2-NUP107-20-GRAQ 20 (40 μL) 200 μL
MDM2-NUP107-20-AQRE 20 (40 μL) 200 μL
MDM2-NUP107-20-AQOR 20 (40 μL) 200 μL
MDM2-NUP107-20-AQGO 20 (40 μL) 200 μL
MDM2-NUP107-20-AQGR 20 (40 μL) 200 μL
MDM2-NUP107-20-AQAQ 20 (40 μL) 200 μL

MDM2 Gene Summary

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Gene Name: MDM2 Proto-oncogene

Chromosome: CHR12: 69201970 -69239212

Locus: 12q15

NUP107 Gene Summary

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Name: Nucleoporin 107

Chromosome: CHR12: 69080730 -69136473

Locus: 12q15

Gene Diseases

The MDM2 NUP107 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma
Lung Adenocarcinoma
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.