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MED1-GSDMB Fusion FISH Probe

The MED1-GSDMB Fusion FISH Probe is used to confirm a fusion of the MED1 and GSDMB genes. The fusion of the MED1 and GSDMB genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MED1-GSDMB-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MED1-GSDMB-20-RERE 20 (40 μL) 200 μL
MED1-GSDMB-20-REOR 20 (40 μL) 200 μL
MED1-GSDMB-20-REGO 20 (40 μL) 200 μL
MED1-GSDMB-20-REGR 20 (40 μL) 200 μL
MED1-GSDMB-20-REAQ 20 (40 μL) 200 μL
MED1-GSDMB-20-ORRE 20 (40 μL) 200 μL
MED1-GSDMB-20-OROR 20 (40 μL) 200 μL
MED1-GSDMB-20-ORGO 20 (40 μL) 200 μL
MED1-GSDMB-20-ORAQ 20 (40 μL) 200 μL
MED1-GSDMB-20-GORE 20 (40 μL) 200 μL
MED1-GSDMB-20-GOOR 20 (40 μL) 200 μL
MED1-GSDMB-20-GOGO 20 (40 μL) 200 μL
MED1-GSDMB-20-GOGR 20 (40 μL) 200 μL
MED1-GSDMB-20-GOAQ 20 (40 μL) 200 μL
MED1-GSDMB-20-GRRE 20 (40 μL) 200 μL
MED1-GSDMB-20-GROR 20 (40 μL) 200 μL
MED1-GSDMB-20-GRGO 20 (40 μL) 200 μL
MED1-GSDMB-20-GRGR 20 (40 μL) 200 μL
MED1-GSDMB-20-GRAQ 20 (40 μL) 200 μL
MED1-GSDMB-20-AQRE 20 (40 μL) 200 μL
MED1-GSDMB-20-AQOR 20 (40 μL) 200 μL
MED1-GSDMB-20-AQGO 20 (40 μL) 200 μL
MED1-GSDMB-20-AQGR 20 (40 μL) 200 μL
MED1-GSDMB-20-AQAQ 20 (40 μL) 200 μL

MED1 Gene Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

Gene Name: Mediator Complex Subunit 1

Chromosome: CHR17: 37560537 -37607527

Locus: 17q12

GSDMB Gene Summary

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]

Gene Name: Gasdermin B

Chromosome: CHR17: 38060847 -38074903

Locus: 17q21.1

Gene Diseases

The MED1 GSDMB Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.