MED15-COMT Fusion FISH Probe
The MED15-COMT Fusion FISH Probe is used to confirm a fusion of the MED15 and COMT genes. The fusion of the MED15 and COMT genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MED15-COMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-RERE | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-REOR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-REGO | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-REGR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-REAQ | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-ORRE | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-OROR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-ORGO | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GORE | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GOOR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GOGO | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GOGR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GRRE | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GROR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GRGO | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GRGR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-AQRE | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-AQOR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-AQGO | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-AQGR | 20 (40 μL) | 200 μL |
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| MED15-COMT-20-AQAQ | 20 (40 μL) | 200 μL |
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COMT Gene Summary
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Gene Name: Catechol-O-methyltransferase
Chromosome: CHR22: 19929262 -19957498
Locus: 22q11.21
MED15 Gene Summary
The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: Mediator Complex Subunit 15
Chromosome: CHR22: 20861885 -20941919
Locus: 22q11.21
Gene Diseases
The MED15 COMT Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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