MED25-SIGLEC12 Fusion FISH Probe
The MED25-SIGLEC12 Fusion FISH Probe is used to confirm a fusion of the MED25 and SIGLEC12 genes. The fusion of the MED25 and SIGLEC12 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MED25-SIGLEC12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-RERE | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-REOR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-REGO | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-REGR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-REAQ | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-ORRE | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-OROR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-ORGO | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-ORAQ | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GORE | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GOOR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GOGO | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GOGR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GOAQ | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GRRE | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GROR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GRGO | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GRGR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-GRAQ | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-AQRE | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-AQOR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-AQGO | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-AQGR | 20 (40 μL) | 200 μL |
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| MED25-SIGLEC12-20-AQAQ | 20 (40 μL) | 200 μL |
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MED25 Gene Summary
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2. [provided by RefSeq, Apr 2010]
Gene Name: Mediator Complex Subunit 25
Chromosome: CHR19: 50321535 -50340237
Locus: 19q13.33
SIGLEC12 Gene Summary
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: Sialic Acid Binding Ig Like Lectin 12 (gene/pseudogene)
Chromosome: CHR19: 51994612 -52005043
Locus: 19q13.41
Gene Diseases
The MED25 SIGLEC12 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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