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MEI1-MKL1 Fusion FISH Probe

The MEI1-MKL1 Fusion FISH Probe is used to confirm a fusion of the MEI1 and MKL1 genes. The fusion of the MEI1 and MKL1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MEI1-MKL1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MEI1-MKL1-20-RERE 20 (40 μL) 200 μL
MEI1-MKL1-20-REOR 20 (40 μL) 200 μL
MEI1-MKL1-20-REGO 20 (40 μL) 200 μL
MEI1-MKL1-20-REGR 20 (40 μL) 200 μL
MEI1-MKL1-20-REAQ 20 (40 μL) 200 μL
MEI1-MKL1-20-ORRE 20 (40 μL) 200 μL
MEI1-MKL1-20-OROR 20 (40 μL) 200 μL
MEI1-MKL1-20-ORGO 20 (40 μL) 200 μL
MEI1-MKL1-20-ORAQ 20 (40 μL) 200 μL
MEI1-MKL1-20-GORE 20 (40 μL) 200 μL
MEI1-MKL1-20-GOOR 20 (40 μL) 200 μL
MEI1-MKL1-20-GOGO 20 (40 μL) 200 μL
MEI1-MKL1-20-GOGR 20 (40 μL) 200 μL
MEI1-MKL1-20-GOAQ 20 (40 μL) 200 μL
MEI1-MKL1-20-GRRE 20 (40 μL) 200 μL
MEI1-MKL1-20-GROR 20 (40 μL) 200 μL
MEI1-MKL1-20-GRGO 20 (40 μL) 200 μL
MEI1-MKL1-20-GRGR 20 (40 μL) 200 μL
MEI1-MKL1-20-GRAQ 20 (40 μL) 200 μL
MEI1-MKL1-20-AQRE 20 (40 μL) 200 μL
MEI1-MKL1-20-AQOR 20 (40 μL) 200 μL
MEI1-MKL1-20-AQGO 20 (40 μL) 200 μL
MEI1-MKL1-20-AQGR 20 (40 μL) 200 μL
MEI1-MKL1-20-AQAQ 20 (40 μL) 200 μL

MKL1 Gene Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Name: Megakaryoblastic Leukemia (translocation) 1

Chromosome: CHR22: 40806291 -41032690

Locus: 22q13.1-q13.2

MEI1 Gene Summary

The Meiotic Double-stranded Break Formation Protein 1 (MEI1) gene is located on chr22 :42095517-42195459 at 22q13.2.

Gene Name: Meiotic Double-stranded Break Formation Protein 1

Chromosome: CHR22: 42095517 -42195459

Locus: 22q13.2

Gene Diseases

The MEI1 MKL1 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.