MFN2-PLOD1 Fusion FISH Probe
The MFN2-PLOD1 Fusion FISH Probe is used to confirm a fusion of the MFN2 and PLOD1 genes. The fusion of the MFN2 and PLOD1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MFN2-PLOD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-RERE | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-REOR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-REGO | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-REGR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-REAQ | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-ORRE | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-OROR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-ORGO | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GORE | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GOOR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GOGO | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GOGR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GRRE | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GROR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GRGO | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GRGR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-AQRE | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-AQOR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-AQGO | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-AQGR | 20 (40 μL) | 200 μL |
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| MFN2-PLOD1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLOD1 Gene Summary
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Chromosome: CHR1: 11994723 -12035599
Locus: 1p36.22
MFN2 Gene Summary
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Mitofusin 2
Chromosome: CHR1: 12040237 -12073572
Locus: 1p36.22
Gene Diseases
The MFN2 PLOD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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