MIB1-CABYR Fusion FISH Probe
The MIB1-CABYR Fusion FISH Probe is used to confirm a fusion of the MIB1 and CABYR genes. The fusion of the MIB1 and CABYR genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MIB1-CABYR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-RERE | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-REOR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-REGO | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-REGR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-REAQ | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-ORRE | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-OROR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-ORGO | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-ORAQ | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GORE | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GOOR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GOGO | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GOGR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GOAQ | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GRRE | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GROR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GRGO | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GRGR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-GRAQ | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-AQRE | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-AQOR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-AQGO | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-AQGR | 20 (40 μL) | 200 μL |
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| MIB1-CABYR-20-AQAQ | 20 (40 μL) | 200 μL |
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CABYR Gene Summary
To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Calcium Binding Tyrosine Phosphorylation Regulated
Chromosome: CHR18: 21718954 -21741564
Locus: 18q11.2
MIB1 Gene Summary
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]
Gene Name: Mindbomb E3 Ubiquitin Protein Ligase 1
Chromosome: CHR18: 19321544 -19450912
Locus: 18q11.2
Gene Diseases
The MIB1 CABYR Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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