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MKNK2-ZFR2 Fusion FISH Probe

The MKNK2-ZFR2 Fusion FISH Probe is used to confirm a fusion of the MKNK2 and ZFR2 genes. The fusion of the MKNK2 and ZFR2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MKNK2-ZFR2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MKNK2-ZFR2-20-RERE 20 (40 μL) 200 μL
MKNK2-ZFR2-20-REOR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-REGO 20 (40 μL) 200 μL
MKNK2-ZFR2-20-REGR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-REAQ 20 (40 μL) 200 μL
MKNK2-ZFR2-20-ORRE 20 (40 μL) 200 μL
MKNK2-ZFR2-20-OROR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-ORGO 20 (40 μL) 200 μL
MKNK2-ZFR2-20-ORAQ 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GORE 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GOOR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GOGO 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GOGR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GOAQ 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GRRE 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GROR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GRGO 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GRGR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-GRAQ 20 (40 μL) 200 μL
MKNK2-ZFR2-20-AQRE 20 (40 μL) 200 μL
MKNK2-ZFR2-20-AQOR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-AQGO 20 (40 μL) 200 μL
MKNK2-ZFR2-20-AQGR 20 (40 μL) 200 μL
MKNK2-ZFR2-20-AQAQ 20 (40 μL) 200 μL

MKNK2 Gene Summary

This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]

Gene Name: MAP Kinase Interacting Serine/threonine Kinase 2

Chromosome: CHR19: 2037469 -2051243

Locus: 19p13.3

ZFR2 Gene Summary

The Zinc Finger RNA Binding Protein 2 (ZFR2) gene is located on chr19 :3804021-3869027 at 19p13.3.

Gene Name: Zinc Finger RNA Binding Protein 2

Chromosome: CHR19: 3804021 -3869027

Locus: 19p13.3

Gene Diseases

The MKNK2 ZFR2 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.