MMD-HDAC5 Fusion FISH Probe
The MMD-HDAC5 Fusion FISH Probe is used to confirm a fusion of the MMD and HDAC5 genes. The fusion of the MMD and HDAC5 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MMD-HDAC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MMD-HDAC5-20-AQAQ | 20 (40 μL) | 200 μL |
|
HDAC5 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 5
Chromosome: CHR17: 42154120 -42201014
Locus: 17q21.31
MMD Gene Summary
This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]
Gene Name: Monocyte To Macrophage Differentiation Associated
Chromosome: CHR17: 53469973 -53499341
Locus: 17q22
Gene Diseases
The MMD HDAC5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|