MPO-STAT6 Fusion FISH Probe
The MPO-STAT6 Fusion FISH Probe is used to confirm a fusion of the MPO and STAT6 genes. The fusion of the MPO and STAT6 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MPO-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| MPO-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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MPO Gene Summary
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Gene Name: Myeloperoxidase
Chromosome: CHR17: 56347216 -56358296
Locus: 17q22
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The MPO STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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