MPP6-OSBPL3 Fusion FISH Probe
The MPP6-OSBPL3 Fusion FISH Probe is used to confirm a fusion of the MPP6 and OSBPL3 genes. The fusion of the MPP6 and OSBPL3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MPP6-OSBPL3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-RERE | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-REOR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-REGO | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-REGR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-REAQ | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-ORRE | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-OROR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-ORGO | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GORE | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GOOR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GOGO | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GOGR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GRRE | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GROR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GRGO | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GRGR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-AQRE | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-AQOR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-AQGO | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-AQGR | 20 (40 μL) | 200 μL |
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| MPP6-OSBPL3-20-AQAQ | 20 (40 μL) | 200 μL |
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OSBPL3 Gene Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: Oxysterol Binding Protein Like 3
Chromosome: CHR7: 24836163 -25019760
Locus: 7p15.3
MPP6 Gene Summary
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
Gene Name: Membrane Palmitoylated Protein 6
Chromosome: CHR7: 24613084 -24727498
Locus: 7p15.3
Gene Diseases
The MPP6 OSBPL3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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