MRPL21-SHANK2 Fusion FISH Probe
The MRPL21-SHANK2 Fusion FISH Probe is used to confirm a fusion of the MRPL21 and SHANK2 genes. The fusion of the MRPL21 and SHANK2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MRPL21-SHANK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-RERE | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-REOR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-REGO | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-REGR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-REAQ | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-ORRE | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-OROR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-ORGO | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GORE | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GOOR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GOGO | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GOGR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GRRE | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GROR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GRGO | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GRGR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-AQRE | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-AQOR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-AQGO | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-AQGR | 20 (40 μL) | 200 μL |
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| MRPL21-SHANK2-20-AQAQ | 20 (40 μL) | 200 μL |
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SHANK2 Gene Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: SH3 And Multiple Ankyrin Repeat Domains 2
Chromosome: CHR11: 70313960 -70935808
Locus: 11q13.3-q13.4
MRPL21 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L21
Chromosome: CHR11: 68658745 -68671303
Locus: 11q13.3
Gene Diseases
The MRPL21 SHANK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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