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MRPL21-SSH3 Fusion FISH Probe

The MRPL21-SSH3 Fusion FISH Probe is used to confirm a fusion of the MRPL21 and SSH3 genes. The fusion of the MRPL21 and SSH3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MRPL21-SSH3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MRPL21-SSH3-20-RERE 20 (40 μL) 200 μL
MRPL21-SSH3-20-REOR 20 (40 μL) 200 μL
MRPL21-SSH3-20-REGO 20 (40 μL) 200 μL
MRPL21-SSH3-20-REGR 20 (40 μL) 200 μL
MRPL21-SSH3-20-REAQ 20 (40 μL) 200 μL
MRPL21-SSH3-20-ORRE 20 (40 μL) 200 μL
MRPL21-SSH3-20-OROR 20 (40 μL) 200 μL
MRPL21-SSH3-20-ORGO 20 (40 μL) 200 μL
MRPL21-SSH3-20-ORAQ 20 (40 μL) 200 μL
MRPL21-SSH3-20-GORE 20 (40 μL) 200 μL
MRPL21-SSH3-20-GOOR 20 (40 μL) 200 μL
MRPL21-SSH3-20-GOGO 20 (40 μL) 200 μL
MRPL21-SSH3-20-GOGR 20 (40 μL) 200 μL
MRPL21-SSH3-20-GOAQ 20 (40 μL) 200 μL
MRPL21-SSH3-20-GRRE 20 (40 μL) 200 μL
MRPL21-SSH3-20-GROR 20 (40 μL) 200 μL
MRPL21-SSH3-20-GRGO 20 (40 μL) 200 μL
MRPL21-SSH3-20-GRGR 20 (40 μL) 200 μL
MRPL21-SSH3-20-GRAQ 20 (40 μL) 200 μL
MRPL21-SSH3-20-AQRE 20 (40 μL) 200 μL
MRPL21-SSH3-20-AQOR 20 (40 μL) 200 μL
MRPL21-SSH3-20-AQGO 20 (40 μL) 200 μL
MRPL21-SSH3-20-AQGR 20 (40 μL) 200 μL
MRPL21-SSH3-20-AQAQ 20 (40 μL) 200 μL

SSH3 Gene Summary

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

Gene Name: Slingshot Protein Phosphatase 3

Chromosome: CHR11: 67070918 -67080078

Locus: 11q13.2

MRPL21 Gene Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

Gene Name: Mitochondrial Ribosomal Protein L21

Chromosome: CHR11: 68658745 -68671303

Locus: 11q13.3

Gene Diseases

The MRPL21 SSH3 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.