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MRPL48-DTX4 Fusion FISH Probe

The MRPL48-DTX4 Fusion FISH Probe is used to confirm a fusion of the MRPL48 and DTX4 genes. The fusion of the MRPL48 and DTX4 genes has been associated with Breast Invasive Carcinoma, Breast Invasive Carcinoma, Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MRPL48-DTX4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MRPL48-DTX4-20-RERE 20 (40 μL) 200 μL
MRPL48-DTX4-20-REOR 20 (40 μL) 200 μL
MRPL48-DTX4-20-REGO 20 (40 μL) 200 μL
MRPL48-DTX4-20-REGR 20 (40 μL) 200 μL
MRPL48-DTX4-20-REAQ 20 (40 μL) 200 μL
MRPL48-DTX4-20-ORRE 20 (40 μL) 200 μL
MRPL48-DTX4-20-OROR 20 (40 μL) 200 μL
MRPL48-DTX4-20-ORGO 20 (40 μL) 200 μL
MRPL48-DTX4-20-ORAQ 20 (40 μL) 200 μL
MRPL48-DTX4-20-GORE 20 (40 μL) 200 μL
MRPL48-DTX4-20-GOOR 20 (40 μL) 200 μL
MRPL48-DTX4-20-GOGO 20 (40 μL) 200 μL
MRPL48-DTX4-20-GOGR 20 (40 μL) 200 μL
MRPL48-DTX4-20-GOAQ 20 (40 μL) 200 μL
MRPL48-DTX4-20-GRRE 20 (40 μL) 200 μL
MRPL48-DTX4-20-GROR 20 (40 μL) 200 μL
MRPL48-DTX4-20-GRGO 20 (40 μL) 200 μL
MRPL48-DTX4-20-GRGR 20 (40 μL) 200 μL
MRPL48-DTX4-20-GRAQ 20 (40 μL) 200 μL
MRPL48-DTX4-20-AQRE 20 (40 μL) 200 μL
MRPL48-DTX4-20-AQOR 20 (40 μL) 200 μL
MRPL48-DTX4-20-AQGO 20 (40 μL) 200 μL
MRPL48-DTX4-20-AQGR 20 (40 μL) 200 μL
MRPL48-DTX4-20-AQAQ 20 (40 μL) 200 μL

DTX4 Gene Summary

The Deltex E3 Ubiquitin Ligase 4 (DTX4) gene is located on chr11 :58939811-58976060 at 11q12.1.

Gene Name: Deltex E3 Ubiquitin Ligase 4

Chromosome: CHR11: 58939811 -58976060

Locus: 11q12.1

MRPL48 Gene Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Gene Name: Mitochondrial Ribosomal Protein L48

Chromosome: CHR11: 73498916 -73575656

Locus: 11q13.4

Gene Diseases

The MRPL48 DTX4 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma
Breast Invasive Carcinoma
Breast Invasive Carcinoma
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.