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MSH2-SPTLC1 Fusion FISH Probe

The MSH2-SPTLC1 Fusion FISH Probe is used to confirm a fusion of the MSH2 and SPTLC1 genes. The fusion of the MSH2 and SPTLC1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MSH2-SPTLC1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MSH2-SPTLC1-20-RERE 20 (40 μL) 200 μL
MSH2-SPTLC1-20-REOR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-REGO 20 (40 μL) 200 μL
MSH2-SPTLC1-20-REGR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-REAQ 20 (40 μL) 200 μL
MSH2-SPTLC1-20-ORRE 20 (40 μL) 200 μL
MSH2-SPTLC1-20-OROR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-ORGO 20 (40 μL) 200 μL
MSH2-SPTLC1-20-ORAQ 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GORE 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GOOR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GOGO 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GOGR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GOAQ 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GRRE 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GROR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GRGO 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GRGR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-GRAQ 20 (40 μL) 200 μL
MSH2-SPTLC1-20-AQRE 20 (40 μL) 200 μL
MSH2-SPTLC1-20-AQOR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-AQGO 20 (40 μL) 200 μL
MSH2-SPTLC1-20-AQGR 20 (40 μL) 200 μL
MSH2-SPTLC1-20-AQAQ 20 (40 μL) 200 μL

MSH2 Gene Summary

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Name: MutS Homolog 2

Chromosome: CHR2: 47630262 -47710360

Locus: 2p21-p16.3

SPTLC1 Gene Summary

This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013]

Gene Name: Serine Palmitoyltransferase Long Chain Base Subunit 1

Chromosome: CHR9: 94793426 -94877690

Locus: 9q22.31

Gene Diseases

The MSH2 SPTLC1 Fusion has been associated with the following diseases:

Disease Name
Uterine Carcinosarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.