MSH3-RASGEF1C Fusion FISH Probe
The MSH3-RASGEF1C Fusion FISH Probe is used to confirm a fusion of the MSH3 and RASGEF1C genes. The fusion of the MSH3 and RASGEF1C genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MSH3-RASGEF1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-RERE | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-REOR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-REGO | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-REGR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-REAQ | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-ORRE | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-OROR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-ORGO | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-ORAQ | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GORE | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GOOR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GOGO | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GOGR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GOAQ | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GRRE | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GROR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GRGO | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GRGR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-GRAQ | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-AQRE | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-AQOR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-AQGO | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-AQGR | 20 (40 μL) | 200 μL |
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| MSH3-RASGEF1C-20-AQAQ | 20 (40 μL) | 200 μL |
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MSH3 Gene Summary
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Gene Name: MutS Homolog 3
Chromosome: CHR5: 79950293 -80172634
Locus: 5q14.1
RASGEF1C Gene Summary
The RasGEF Domain Family Member 1C (RASGEF1C) gene is located on chr5 :179527794-179636130 at 5q35.3.
Gene Name: RasGEF Domain Family Member 1C
Chromosome: CHR5: 179527794 -179636130
Locus: 5q35.3
Gene Diseases
The MSH3 RASGEF1C Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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