MSH5-BSCL2 Fusion FISH Probe
The MSH5-BSCL2 Fusion FISH Probe is used to confirm a fusion of the MSH5 and BSCL2 genes. The fusion of the MSH5 and BSCL2 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MSH5-BSCL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-RERE | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-REOR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-REGO | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-REGR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-REAQ | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-ORRE | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-OROR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-ORGO | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GORE | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GOOR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GOGO | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GOGR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GRRE | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GROR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GRGO | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GRGR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-AQRE | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-AQOR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-AQGO | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-AQGR | 20 (40 μL) | 200 μL |
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| MSH5-BSCL2-20-AQAQ | 20 (40 μL) | 200 μL |
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MSH5 Gene Summary
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Gene Name: MutS Homolog 5
Chromosome: CHR6_mcf_hap5: 3087408 -3110152
Locus: 6p21.33
BSCL2 Gene Summary
This gene encodes the multi-pass transmembrane protein protein seipin. This protein localizes to the endoplasmic reticulum and may be important for lipid droplet morphology. Mutations in this gene have been associated with congenital generalized lipodystrophy type 2 or Berardinelli-Seip syndrome, a rare autosomal recessive disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U-like 2).[provided by RefSeq, Mar 2011]
Gene Name: BSCL2, Seipin Lipid Droplet Biogenesis Associated
Chromosome: CHR11: 62457733 -62477091
Locus: 11q12.3
Gene Diseases
The MSH5 BSCL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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